The "interference effect" — the idea that endurance training blunts strength and muscle gains — has worried athletes for decades. The research shows it's real, but far more manageable than most people think.
The Original Discovery
Robert Hickson (1980), in a landmark study published in the European Journal of Applied Physiology, was the first to document that combining heavy strength training with high-volume endurance training compromised strength gains compared to strength training alone. This study launched decades of "cardio kills gains" anxiety.
However, Hickson's protocol was extreme: subjects performed both heavy squats and 40 minutes of intense running or cycling 6 days per week. This is far beyond what most people actually do.
Modern Understanding
Wilson et al. (2012), in a comprehensive meta-analysis of 21 studies published in the Journal of Strength and Conditioning Research, quantified the interference effect more precisely:
- Hypertrophy: Concurrent training reduced muscle growth by a small but significant amount — approximately 10-15% less than strength training alone.
- Maximal strength: Moderately affected, with about 8-12% less improvement.
- Power and explosive performance: Most affected, with reductions of 15-20%.
- Running was more interfering than cycling: The eccentric muscle damage from running created more interference than cycling, which is more concentric in nature.
Minimizing Interference
Baar (2014), in a review published in Sports Medicine, identified the molecular mechanisms behind interference: endurance training activates the AMPK pathway (catabolic), which can suppress the mTOR pathway (anabolic) activated by strength training. Based on this, he proposed practical solutions:
- Separate sessions by 6+ hours: This allows the molecular signals from each session to peak without directly competing. Morning strength, evening cardio (or vice versa).
- If you must combine: Do strength first, endurance second. Strength training when fresh produces better neuromuscular adaptations.
- Fuel adequately: Interference is amplified in a caloric deficit. Eating enough — particularly protein (1.6-2.2g/kg) and carbohydrates — mitigates much of the interference.
- Limit running volume: If muscle/strength is the priority, keep running to 2-3 sessions per week of 20-40 minutes. Or substitute cycling, which causes less interference.
Practical Programming
For an athlete wanting both strength and endurance:
- Monday AM: Lower body strength / PM: Easy 30min run or rest
- Tuesday: 45-60min endurance session (moderate intensity)
- Wednesday AM: Upper body strength / PM: Easy 30min run or rest
- Thursday: Rest or active recovery
- Friday AM: Full body strength / PM: Interval session
- Saturday: Long easy endurance session
- Sunday: Rest
The key: prioritize whichever modality matters more to your goals earlier in the day and earlier in the week, when you're freshest.
Key Takeaway
References
- Hickson, R.C. (1980). Interference of strength development by simultaneously training for strength and endurance. European Journal of Applied Physiology, 45(2-3), 255-263.
- Wilson, J.M. et al. (2012). Concurrent training: a meta-analysis examining interference of aerobic and resistance exercises. Journal of Strength and Conditioning Research, 26(8), 2293-2307.
- Baar, K. (2014). Using molecular biology to maximize concurrent training. Sports Medicine, 44(Suppl 2), 117-125.
- Murach, K.A. & Bagley, J.R. (2016). Skeletal muscle hypertrophy with concurrent exercise training. Sports Medicine, 46(8), 1029-1039.